Ask a centenarian the secret ingredients to a long and healthy life and you aren’t likely to hear “doctors, drugs, and fad diets.” We all know that there’s more to our overall well-being than treating symptoms or the occasional replacement of a part. The good news is that scientists in various fields are discovering ever more ways we can keep ourselves healthy without expensive medication and complicated workout regimens. Here are nine simple, scientifically proven—and sometimes surprising—ways to empower yourself to make the right choices for your body and health.
A second chemical pathway of interest when considering therapeutic applications of berberine to diabetes is the aldose reductase pathway. Aldose reductase is the rate-limiting enzyme in the polyol pathway. It reduces glucose to sorbitol using NADPH (nicotinamide adenine dinucleotide phosphate) as a cofactor. Sorbitol is then metabolized to fructose by sorbitol dehydrogenase. In healthy people, only a small amount of glucose (less than 3%) moves through this pathway. However, in the presence of high glucose levels, as much as 30% of total glucose will follow this path. In diabetics, this abnormal flow of glucose down the polyol pathway leads to the accumulation of large amounts of sorbitol, which in turn leads to both osmotic and oxidative stress in the tissues where sorbitol accumulates. 51 Aldose reductase plays a significant role in much of the pathology caused by diabetes, including diabetic neuropathy, retinopathy, and nephropathy. 52
Dr. Alex received his undergraduate degree from Iowa State University and began a career as an exercise physiologist in 1981. Dr Alex returned to school and graduated from Los Angeles College of Chiropractic and has practiced with a primary interest in workers’ compensation. He was an assistant professor in the clinical sciences department and has had extensive experience in postgraduate teaching in the rehabilitation and sports physician programs. He has worked with the insurance companies within utilization review, determining medical necessity for chiropractic and developing musculoskeletal injury care protocols. His commitment is to functional restoration of the patient that is safe, effective, evidence-based and efficient for the best possible outcomes. Dr. Alex enjoys working out, golf, football (Steelers fan), wrestling, sailing, surfing, scuba diving and kayaking.