Methandrostenolone is a 17-alpha-alkylated oral anabolic-androgenic steroid with anabolic properties that are more pronounced than its androgenic effects. It has little progestational activity and easily converts to estrogens. Methandrostenolone has an anabolic activity index and an androgenic activity index . Methandrostenolone has an extra double bond in the A-ring and, therefore, is not converted by 5-alpha reduction into DHT. Since methandrostenolone was created in the 1 960s, it has been used for many different applications. At present, the only legitimate therapeutic indications for this anabolic steroid are: replacement of male sex steroids in men who have androgen deficiency, for example as a result of loss of both testes: the treatment of certain rare forms of aplastic anemia which are or may be responsive to anabolic androgens: and, In certain countries, to counteract catabolic states, for example after major trauma.
To strengthen the anabolic properties of testosterone, more than 100 synthetic steroid derivatives have been described for human purposes. The anabolic effect promotes protein synthesis, muscle growth and erythropoiesis. In clinical practice, substances with anabolic effect are needed to overcome various catabolic states. However, none of these compounds are devoid of androgenicity. Androgenic and anabolic properties of anabolic steroids cannot be totally separated. Therefore, it is more appropriate to use the term anabolic androgenic steroids (AAS).
Methandienone is a derivative of testosterone, exhibiting strong anabolic and moderate androgenic properties. This compound was first made available in 1960, and it quickly became the most favoured and widely used anabolic steroid in all forms of athletics. This is likely due to the fact that it is both easy to use and extremely effective. In the . Dianabol production had meteoric history, exploding for quite some time, then quickly dropping out of sight. Many were nervous in the late 80's when the last of the . generics were removed from pharmacy shelves, the medical community finding no legitimate use for the drug anymore. But the fact that Dianabol has been off the . market for over 10 years now has not cut its popularity. It remains the most commonly used black market oral steroid in the . As long as there are countries manufacturing this steroid, it will probably remain so.
Similar to testosterone and Anadrol 50, Methandienone (other known as Dianabol) is a potent steroid, but also one which brings about noticeable side effects. For starters methandienone is quite estrogenic. Gynecomastia is often a concern during treatment, and may present itself quite early into a cycle (particularly when higher doses are used). At the same time water retention can become a pronounced problem, causing a notable loss of muscle definition as both subcutaneous water and fat build. Sensitive individuals may therefore want to keep the estrogen under control with the addition of an anti-estrogen such as Nolvadex and/or Proviron. The stronger drugs Arimidex, Femara, or Aromasin (antiaromatase) would be a better choice if available.