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THG, also known as 17α-ethyl-18-methyl-δ 9,11 -19-nortestosterone or as 17α-ethyl-18-methylestra-4,9,11-trien-17β-ol-3-one, is a synthetic estrane steroid and a 17α-alkylated derivative of nandrolone (19-nortestosterone). It is a modification of gestrinone (17α-ethynyl-18-methyl-19-nor-δ 9,11 -testosterone) in which the ethynyl group has been hydrogenated into an ethyl group , thereby converting the steroid from a norethisterone (17α-ethynyl-19-nortestosterone) derivative with weak AR activity into a norethandrolone (17α-ethyl-19-nortestosterone) derivative with powerful AR activity. THG is closely related to RU-2309 (the 17α-methyl variant), trenbolone (δ 9,11 -19-nortestosterone), metribolone (17α-methyl-δ 9,11 -19-nortestosterone), and norboletone (17α-ethyl-18-methyl-19-nortestosterone).